Peroxiredoxin



Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. The images at the left and at the right correspond to one representative Prx, i.e. the crystal structure of Peroxiredoxin from rat (1qq2).

3D Structures of Peroxiredoxin
1qq2 – 2Cys-Prx – rat

2c0d – Pf2Cys-Prx – Plasmodium falciparum

1xiy – Pf1Cys-Prx

1xcc, 2h01 - 1Cys-Prx – Plasmodium yoelii

2i81 - 2Cys-Prx – Plasmodium vivax

1qmv - h2Cys-Prx – human

2rii, 3hy2 – hPrx 1 (mutant)+sulfiredoxin 1

2z9s – Prx 1 (mutant) - rat

2pn8 – hPrx 4

1urm – hPrx 5 (mutant) – human

2vl2, 2vl3, 2vl9, 1h4o, 1hd2, 1oc3 – hPrx 5

3mng – hPrx 5+DTT

2wfc – lPrx 5 - lugworm

2v2g – lPrx 6

2v32, 2v41 – lPrx 6 (mutant)

2a4v – yPrx dot5 C-termianl (mutant) – yeast

3cmi – yPrx hyr1

1tp9 – Prx II – Populus trichocarpa

2pwj – Prx II – garden pea

1uul - 2Cys-Prx – Trypanosoma cruzi

1we0 – Prx – Amphibacillus xylanus

1zye – Prx III (mutant) – bovine

2cv4, 2cx3, 2cx4 – Prx – Aeropyrum pernix

3drn – SsPrx – Sulfolobus solfataricus

3hjp – SsPrx (mutant)

3ixr – Prx PRXQ (mutant) – Xylella fastidiosa